Ptychographic X-ray computed tomography at the nanoscale
Nature. 2010; 467:436-9.
In this letter, a novel X-ray computed tomography technique at the nanoscale is described, which was successfully applied to quantitatively assess the local bone density and to resolve the osteocyte lacuno-canalicular network (see picture) at a resolution below 100 nm.
Hierarchical microimaging of bone structure and function
Nature Rev Rheumatol. 2009 Jul;5(7):373-81.
In this review, strategies for new three-dimensional approaches for functional imaging in the study of micro- and ultrastructural bone are presented. The focus is on hierarchical assessment of bone failure using combined experimental and computational approaches.
Modern biomechanical investigations of the human body include the mechanics of the musculo-skeletal system and movement control from a macroscopic (organs) level down to a microscopic (cells) level, the basic elements of life and growth.
Many diseases like osteoporosis, arthritis, or muscle atrophy lead to reduced strength of the tissues concerned. At risk are the elderly and/or immobilized people due to age, illness, or injury and astronauts in a microgravity environment. To be able to monitor this risk in an early stage of development and to quantify optimal treatment and rehabilitation results is crucial for the welfare of society.
At our Institute we focus on the "musculo-skeletal system of the human body" and we are interested in the material properties of mammalian tissue. To quantify changes and adaptations of these materials through ontogenesis (from birth to death), and the plasticity (adaptation to mechanical demands) of these materials are of prime interest. In contrast to inorganic materials, biological tissue can change its mechanical properties to fulfill the requirements of work, leisure, and even in peak performance sports activities.
The Institute for Biomechanics is a multidisciplinary research unit dedicated to the biomechanical investigation of the human body. It currently consists of three professorships covering different areas of musculo-skeletal biomechanics.
Diese Website wird in älteren Versionen von Netscape ohne graphische Elemente dargestellt. Die Funktionalität der Website ist aber trotzdem gewährleistet. Wenn Sie diese Website regelmässig benutzen, empfehlen wir Ihnen, auf Ihrem Computer einen aktuellen Browser zu installieren. Weitere Informationen finden Sie auf
The content in this site is accessible to any browser or Internet device, however, some graphics will display correctly only in the newer versions of Netscape. To get the most out of our site we suggest you upgrade to a newer browser.