Student Projects

Main content

ETH Zurich uses SiROP to publish and search scientific projects. For more information visit www.sirop.org.

Zenobi-Wong Group / Cartilage Engineering and Regeneration

Development medical adhesives for cartilage tissue

For the successful integration of an engineered cartilage tissue graft, the graft should be stably attached on the damaged tissue site. In this project, we aim at developing pressure-inducible tissue adhesives for cartilage damage repair. Show details 

Müller Group / Laboratory for Bone Biomechanics

Quantitative Analysis of Osteocyte Lacunae

State of the art microCT has allowed researchers to visualise the cell containing voids in the bone, know as lacunae. However analysis of such images is complicated by artefacts caused by physical limitations in the technology. This project aims to develop algorithms to correct for such artefacts. Show details 

Müller Group / Laboratory for Bone Biomechanics

Image-Registration in Fractured Bone

Image registration is an essential tool in bone research, yet existing software can only deal with easy geometries like healthy bone or single fractures. Therefore, the present study will investigate possibilities to register 3D images with higher geometrical complexity. Show details 

Würtz-Kozak Group / Immunoengineering and Regenerative Medicine

Changes in the expression of mechanosensors with age and degeneration

This project will investigate whether and how the expression of a specific group of mechanosensors – the TRP Channels – changes with age and degeneration in the human intervertebral disc. Methods used in this project will include qPCR, immunohistochemistry and immunoblotting to investigate expressio Show details 

Taylor Group / Dual-Plane Fluoroscope

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Adaption and implementation of two fluoroscopic C-Arms

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Adaption and implementation of two fluoroscopic C-Arms Show details 

Taylor Group / Dual-Plane Fluoroscope

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Design and validation of the electrical drive system (vertical axis)

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Design and validation of the electrical drive system (vertical axis) Show details 

Taylor Group / Dual-Plane Fluoroscope

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Implementation of a tracking system – Feedback control algorithm

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Implementation of a tracking system – Feedback control algorithm Show details 

Taylor Group / Dual-Plane Fluoroscope

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: 2 Positions: Design and validation of the mechanical drive (vertical axis)

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: 2 Positions: Design and validation of the mechanical drive (vertical axis) Show details 

Taylor Group / Dual-Plane Fluoroscope

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Definition of biomechanical and technical parameters

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Definition of biomechanical and technical parameters Show details 

Taylor Group / Dual-Plane Fluoroscope

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: DuoFluo Operating System

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: DuoFluo Operating System Show details 

Taylor Group / Dual-Plane Fluoroscope

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Design and validation of the electrical driveway (horizontal axis)

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Design and validation of the electrical driveway (horizontal axis) Show details 

Taylor Group / Dual-Plane Fluoroscope

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Implementation of a real-time tracking system – evaluation and testing

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Implementation of a real-time tracking system – evaluation and testing Show details 

Taylor Group / Dual-Plane Fluoroscope

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: 2 Positions: Design and validation of the mechanical driveway (horizontal axis)

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: 2 Positions: Design and validation of the mechanical driveway (horizontal axis) Show details 

Taylor Group / Laboratory for Movement Biomechanics

Clinical application: Assess gait variability parameters with inertial sensors (IMU)

This project focuses on the development and implementation of new gait analysis algorithms for use with our new inertial measurement units (IMUs), as well as their comparison with existing solutions and validation against motion capture data. Show details 

Müller Group / Laboratory for Bone Biomechanics

Mechano-regulation of bone repair and improvement of compromised defect healing

Delayed fracture repair and formation of non-unions is a major issue in orthopedic surgery. In order to better understand the complex mechanism of mechano-molecular regulation of fracture repair and to assess potential treatment approaches, we use standardized preclinical defect models in mice. Show details 

Tissue Mechanobiology

Real time biological and micromechanical characterisation of live spinal disk tissue for spinal disc repair and tissue engineering.

Real time micromechanical and microstructural characterisation of outer layers of intervertebral disc (annulus fibrosus) through 3D light imaging techniques for enhanced understanding of spinal disk biomechanics. Show details 

Tissue Mechanobiology

Novel electrospun scaffolds for spinal disc repair. Mechanics, biocompatibility and application.

Real time biomechanical characterisation of electrospun polymer scaffolds through 3D light imaging techniques for spinal repair. Show details 

Tissue Mechanobiology

Electrospun polymer nanofibers for tissue engineering and regenerative medicine.

Micromechanical and biological characterization of electro spun polycaprolactone nanofibers for tissue engineering scaffolds and regenerative medicine. Show details 

Snedeker Group / Laboratory for Orthopaedic Biomechanics

Isolation of circulating tumor cells by adhesive properties

Establishment of an isolation method for sarcoma circulating tumor cells based on cell-matrix adhesion properties Show details 

Snedeker Group / Laboratory for Orthopaedic Biomechanics

The influence of microfabricated surface topography and dimensionality on cell adhesion and cellular traction in cancer and stem cells.

Cell generated traction forces and the sensing of the mechanical environment of a cell is vital to the fate of cell lines such as stem cells or cancer metastasis. In this project, the critical factors on surface topography and dimensionality should be found and investigated. Show details 

Snedeker Group / Laboratory for Orthopaedic Biomechanics

3D model of Cells and Simulation of Cell tractions

Physical forces generated by cells to its surrounding has been shown to be highly important to its function. In this project, 3D model of cells should be developed that can be used in simulations Show details 

Müller Group / Laboratory for Bone Biomechanics

Mapping bone cells in vivo within their 3D environment

Bone remodeling is a dynamic process that requires coordinated interactions between different bone cell types. In order to further our understanding in bone metabolism, these cellular networks and their micro-environments must be investigated locally in a site specific manner. Show details 

Musculoskeletal Biomechanics

2D/3D rigid image registration for in vivo 3D kinematic analysis of the hip joint.

Implementation and development of an accurate and fast 2D/3D image registration method for estimation of the 3D pose of the hip joint from fluoroscopic images. Show details 

Musculoskeletal Biomechanics

In vivo 3D kinematic analysis of the hip joint during activities of daily living

Retrieval of the in vivo kinematics of the prosthetic hip joint by means of a movable robotic fluoroscope combined with motion capture and 2D-3D registration Show details 

Bone Pathologies and Treatment

Finite Element simulations of a side-ways fall to the hip: Investigation of influence of the upper body

X-ray Computed Tomography (CT) based Finite element models have the potential to improve the prediction of hip fracture risk for osteoporotic patients compared to current standard of diagnosis. The aim of this project is to use such models for investigating the influence of modelling the Show details 

Bone Pathologies and Treatment

Finite Element simulations of a side-ways fall to the hip: Investigation of critical and non-critical fall alignment

X-ray Computed Tomography (CT) based Finite element models have the potential to improve the prediction of hip fracture risk for osteoporotic patients compared to current standard of diagnosis. The aim of this project is to use such models for investigating the influence of leg and pelvic Show details 

Bone Pathologies and Treatment

Finite Element simulations of a side-ways fall to the hip: Identification of critical material parameters

X-ray Computed Tomography (CT) based Finite element models have the potential to improve the prediction of hip fracture risk for osteoporotic patients compared to current standard of diagnosis. The aim of this project is to use such models for investigating the influence of material param Show details 

Würtz-Kozak Group / Immunoengineering and Regenerative Medicine

How do cells sense mechanical loading?

This project will investigate how cells sense mechanical loading and how sensing can be altered with ageing or tissue degeneration. The project is interdisciplinary and includes engineering and biology aspects. The thematic emphasis can be adjusted to the student's background and interests. Show details 

Ferguson Group / Laboratory for Orthopaedic Technology

Predictive Wear Modelling of Total Hip Replacements under Standard and Adverse Loading Conditions

This project aims at predicting the wear behavior of total hip replacements under realistic loading conditions by means of finite element modelling. Show details 

Würtz-Kozak Group / Immunoengineering and Regenerative Medicine

Anti-inflammatory particles for the treatment of intervertebral disc degeneration

Goal of this project is to develop a novel anti-inflammatory microparticle formulation as a regenerative strategy for the intervertebral disc. Show details 

Zenobi-Wong Group / Cartilage Engineering and Regeneration

Surface-immobilization of enzymes using mussel-inspired approaches and its application for surface-mediated hydrogel formation

Enzyme-immobilized surfaces can provide a platform for in situ crosslinking of hydrogels. Several enzyme-mediated hydrogel systems will be explored throughout the project. The immobilization methods will be optimized considering enzyme activities and efficiencies of hydrogel formation. Show details 

ETH Zurich

Strength training

Kinetic and kinematic measurement during strength training exercise is the basis for inverse dynamic and modeling. The aim is to understand the loading conditions during training in oder to compare exercises and find evidence for rules and recommendation. Show details 

Sports Biomechanics Group

Influence of Backpack Weight and Hip Belt Tension on different gait parameter

Discomfort is a subjective perception and it can directly influence the user acceptance of a load carriage system. The influence of backpack with different load on the gait parameters is barely known. The goal is to analyze the effects of backpack load on kinetics and kinematics. Show details 

Würtz-Kozak Group / Immunoengineering and Regenerative Medicine

The role of early trauma on bone structure

In this project, the effects of early trauma on bone structure will be analyzed by microCT. Show details 

Snedeker Group / Laboratory for Orthopaedic Biomechanics

Assessment of the impact of intermittent mechanical loading in the early stages of tendinopathy on tendon healing

The aim of this project is to analyze the effects of intermittent loading on primary human tenocytes seeded on aligned and random oriented electrospun fiber scaffolds that mimic healthy and degenerated tendons, respectively. Show details 

Snedeker Group / Laboratory for Orthopaedic Biomechanics

Insilico Cell Mechanics: Finite Element Modelling of cell behaviour in mechanical characterisation

In our group we experimentally analyze the resistance of cells to substrate deformations. In the present project we plan to generate a finite element model of the cell response to biaxial stretching and use it to estimate cell stiffness from the experimental outcomes. Show details 

Würtz-Kozak Group / Immunoengineering and Regenerative Medicine

Development of smart, antimicrobial implant coatings for open fracture stabilization

This project will combine literature review with experimental work, with the overall goal to develop smart, antimicrobial implant coatings. Show details 

Snedeker Group / Laboratory for Orthopaedic Biomechanics

Recording in real-time: development and implementation of real-time 3D tracking algorithms for observation of biological samples.

The spatio-temporal changes of a living organism happen in real time. Observation of these changes is highly challenging even with cutting edge recording techniques. We are aiming to push this limit with our recently developed functional imaging platform. Show details 

Snedeker Group / Laboratory for Orthopaedic Biomechanics

Generation and biomechanical characterization of artificial actomyosin cortices in vitro

The complexity of biological materials is a major limiting factor for the discovery of the basic cues that govern the metastatic process. With this in mind, the selected student will participate in the development of an in vitro model of metastasizing cells. Show details 

Sports Biomechanics Group

Loading patterns of the Medial Collateral Ligament (MCL) and Lateral Collateral Ligament (LCL) in healthy knees. A systematic review

Loading patterns of the collateral ligaments of the knee have been investigated using a variety of techniques. Aggregating the available data reported by single studies in a systematic review can provide a clear unbiased consensus on the loading of the collateral ligaments. Show details 

Snedeker Group / Laboratory for Orthopaedic Biomechanics

Evaluation of morphology dependent mechanical properties of stem cells

Aim of the project: Revealing how does the cell morphology determine the mechanical properties of the cell? Show details 

Würtz-Kozak Group / Immunoengineering and Regenerative Medicine

How can propionibacterium acnes cause back pain?

The aim of this project is to identify molecular mechanisms that may be explain pain development upon bacterial infection of the intervertebral disc, specifically by propionibacterium acnes. Show details 

Snedeker Group / Laboratory for Orthopaedic Biomechanics

Gene expression-based purification of primary tenocytes using novel nanostructured RNA probes

The aim of this project is to purify a homogenous population of primary tenocytes from the mouse tail tendons by targeting the gene expression of the tenogenic markers (COLIA2, Scleraxis, and Tenomodulin or Decorin). Show details 

Snedeker Group / Laboratory for Orthopaedic Biomechanics

Engineering the Diabetic Tendon Microenvironment

This project aims to engineer a synthetic hydrogel-based cell niche that mimics key aspects of the diabetic tendon extracellular matrix. Patient-derived tendon fibroblasts will be used to construct a more physiologically relevant three-dimensional (3D) model. Show details 

Snedeker Group / Laboratory for Orthopaedic Biomechanics

The role of tendon matrix composition in regulating tenocytes fate: A tissue engineering approach.

The goal of this project is to create a 3D in vitro model to study tendon cell-ECM interaction using collagen gels and primary rat tenocytes. Show details 

Snedeker Group / Laboratory for Orthopaedic Biomechanics

Comparative biochemical and proteomic analysis of healthy and diseased human tendons

The objectives of this project strive to develop the experimental workflow protocol to analyze the matrix composition of healthy and diseased human tendons. This includes samples preparation, immunostaining, separation and identification of proteins using different mass spectroscopy techniques. Show details 

Snedeker Group / Laboratory for Orthopaedic Biomechanics

Tendon-on-a-Chip: Developing and characterizing a multi-channels microfluidic device for studying tendon biology

This goal of this project is to refine and characterize a novel approach in designing microfluidic networks that allow to host tendon-like micro-tissue structures for long-term culturing experiments under mechanical stimulation. Show details 

Würtz-Kozak Group / Immunoengineering and Regenerative Medicine

Electrospun Wound Dressings

Dressings for chronic wounds should alleviate symptoms, provide wound protection, encourage healing and exert antimicrobial effects in case of infection. As none of the current dressings fulfills all these requirements, the project goal is to create smart wound dressings with improved functionality. Show details 

Müller Group / Laboratory for Bone Biomechanics

Updating Micro-FE Meshes in Computational Simulations of Bone Tissue Remodelling

Local tissue loading is probably the most important factor triggering bone remodelling. To calculate tissue loading, micro-FE analysis is often used. The purpose of this study is to develop an efficient way of updating FE meshes in bone remodelling simulations that require iterative FE analysis. Show details 

 
 
Page URL: http://www.biomech.ethz.ch/student-projects.html
Sun Apr 23 01:59:13 CEST 2017
© 2017 Eidgenössische Technische Hochschule Zürich