Student Projects

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ETH Zurich uses SiROP to publish and search scientific projects. For more information visit www.sirop.org.

Müller Group / Laboratory for Bone Biomechanics

Biomimetic osteocyte culture in 3D printed structures

Osteocytes are widely accepted to be the main mechanosensor in bone. Using micro 3D printing, advanced surface coating technology and live cell microscopy, we are establishing a novel 3D cell model to study the mechanotransduction mechanisms at play. Show details 

Müller Group / Laboratory for Bone Biomechanics

Mapping bone cells in vivo within their 3D environment

Bone remodeling is a dynamic process that requires coordinated interactions between different bone cell types. In order to further our understanding in bone metabolism, these cellular networks and their micro-environments must be investigated locally in a site specific manner. Show details 

Snedeker Group / Laboratory for Orthopaedic Biomechanics

Insilico Cell Mechanics: Finite Element Modelling of cell behaviour in mechanical characterisation

In our group we experimentally analyze the resistance of cells to substrate deformations. In the present project we plan to generate a finite element model of the cell response to biaxial stretching and use it to estimate cell stiffness from the experimental outcomes. Show details 

Snedeker Group / Laboratory for Orthopaedic Biomechanics

Recording in real-time: development and implementation of real-time 3D tracking algorithms for observation of biological samples.

The spatio-temporal changes of a living organism happen in real time. Observation of these changes is highly challenging even with cutting edge recording techniques. We are aiming to push this limit with our recently developed functional imaging platform. Show details 

Snedeker Group / Laboratory for Orthopaedic Biomechanics

Shape it up: controlled cell morphology relation to mechanical properties

In our group we experimentally characterize the mechanical properties of cells. In the present project we plan to develop and optimize microstructure fabrication techniques to drive cell attachment to well defined patterns to achieve controlled cell shape. Show details 

Würtz-Kozak Group / Immunoengineering and Regenerative Medicine

How do cells sense mechanical loading?

This project will investigate how cells sense mechanical loading and how sensing can be altered with ageing or tissue degeneration. The project is interdisciplinary and includes engineering and biology aspects. The thematic emphasis can be adjusted to the student's background and interests. Show details 

Würtz-Kozak Group / Immunoengineering and Regenerative Medicine

Anti-inflammatory particles for the treatment of intervertebral disc degeneration

Goal of this project is to develop a novel anti-inflammatory microparticle formulation as a regenerative strategy for the intervertebral disc. Show details 

ETH Zurich

Strength training

Kinetic and kinematic measurement during strength training exercise is the basis for inverse dynamic and modeling. The aim is to understand the loading conditions during training in oder to compare exercises and find evidence for rules and recommendation. Show details 

Würtz-Kozak Group / Immunoengineering and Regenerative Medicine

The role of early trauma on bone structure

In this project, the effects of early trauma on bone structure will be analyzed by microCT. Show details 

Würtz-Kozak Group / Immunoengineering and Regenerative Medicine

Development of smart, antimicrobial implant coatings for open fracture stabilization

This project will combine literature review with experimental work, with the overall goal to develop smart, antimicrobial implant coatings. Show details 

Taylor Group / Dual-Plane Fluoroscope

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Adaption and implementation of two fluoroscopic C-Arms

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Adaption and implementation of two fluoroscopic C-Arms Show details 

Taylor Group / Dual-Plane Fluoroscope

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Design and validation of the electrical drive system (vertical axis)

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Design and validation of the electrical drive system (vertical axis) Show details 

Taylor Group / Dual-Plane Fluoroscope

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Implementation of a tracking system – Feedback control algorithm

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Implementation of a tracking system – Feedback control algorithm Show details 

Taylor Group / Dual-Plane Fluoroscope

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: 2 Positions: Design and validation of the mechanical drive (vertical axis)

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: 2 Positions: Design and validation of the mechanical drive (vertical axis) Show details 

Taylor Group / Dual-Plane Fluoroscope

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Definition of biomechanical and technical parameters

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Definition of biomechanical and technical parameters Show details 

Taylor Group / Dual-Plane Fluoroscope

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: DuoFluo Operating System

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: DuoFluo Operating System Show details 

Taylor Group / Dual-Plane Fluoroscope

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Design and validation of the electrical driveway (horizontal axis)

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Design and validation of the electrical driveway (horizontal axis) Show details 

Taylor Group / Dual-Plane Fluoroscope

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Implementation of a real-time tracking system – evaluation and testing

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: Implementation of a real-time tracking system – evaluation and testing Show details 

Taylor Group / Dual-Plane Fluoroscope

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: 2 Positions: Design and validation of the mechanical driveway (horizontal axis)

Development of a Tracking Dual-plane Fluoroscope for assessing musculoskeletal and orthopaedic kinematics: 2 Positions: Design and validation of the mechanical driveway (horizontal axis) Show details 

Taylor Group / Laboratory for Movement Biomechanics

Clinical application: Assess gait variability parameters with inertial sensors (IMU)

This project focuses on the development and implementation of new gait analysis algorithms for use with our new inertial measurement units (IMUs), as well as their comparison with existing solutions and validation against motion capture data. Show details 

Müller Group / Laboratory for Bone Biomechanics

Implementing a mechanical testing methodology for assessing the flexure stiffness of healed mouse femurs

Assessing the mechanical properties of healed mouse femurs with three point bending tests poses a challenge due to certain test artifacts. Implementation of an experimental, imaging and computational approach will allow accurate determination of these properties. Show details 

Snedeker Group / Laboratory for Orthopaedic Biomechanics

Evaluation of morphology dependent mechanical properties of stem cells

Aim of the project: Revealing how does the cell morphology determine the mechanical properties of the cell? Show details 

Würtz-Kozak Group / Immunoengineering and Regenerative Medicine

Nutraceutical-based treatment of inflammatory bowel disease

Inflammatory Bowel disease (IBD) affects ~5 million people worldwide. We aim to develop of a targeted functional food would help improve the daily lives of those suffering from IBD. Show details 

Rehabilitation Engineering Lab

How does perturbing the knee modify kinematic variability and dynamic stability during walking?

Although humans are very good at maintaining balance while walking, how it is achieved is poorly understood. Our goal is to better understand dynamic balance control by describing responses to perturbations to the gait pattern, for example, by locking the knee joint during swing phase. In this project, you will assess the effects of knee locking on kinematic variability as well as dynamic stability during walking. Show details 

Würtz-Kozak Group / Immunoengineering and Regenerative Medicine

Hypoxia-related stress responses in skin and aging

The skin is an important barrier against environmental insults but susceptable to hypoxia-mediated degradation during aging. We will investigate the mechanisms by which hypoxia produces an aging phenotype. Show details 

Würtz-Kozak Group / Immunoengineering and Regenerative Medicine

How can propionibacterium acnes cause back pain?

The aim of this project is to identify molecular mechanisms that may be explain pain development upon bacterial infection of the intervertebral disc, specifically by propionibacterium acnes. Show details 

Snedeker Group / Laboratory for Orthopaedic Biomechanics

Engineering the Diabetic Tendon Microenvironment

This project aims to engineer a synthetic hydrogel-based cell niche that mimics key aspects of the diabetic tendon extracellular matrix. Patient-derived tendon fibroblasts will be used to construct a more physiologically relevant three-dimensional (3D) model. Show details 

Snedeker Group / Laboratory for Orthopaedic Biomechanics

The role of tendon matrix composition in regulating tenocytes fate: A tissue engineering approach.

The goal of this project is to create a 3D in vitro model to study tendon cell-ECM interaction using collagen gels and primary rat tenocytes. Show details 

Snedeker Group / Laboratory for Orthopaedic Biomechanics

Tendon-on-a-Chip: Developing and characterizing a multi-channels microfluidic device for studying tendon biology

This goal of this project is to refine and characterize a novel approach in designing microfluidic networks that allow to host tendon-like micro-tissue structures for long-term culturing experiments under mechanical stimulation. Show details 

Zenobi-Wong Group / Tissue Engineering and Biofabrication

The regulatory role of lumican in the TLR4-mediated innate immune response of Osteoarthritis

The regulatory role of lumican in the TLR4-mediated innate immune response of Osteoarthritis Show details 

Würtz-Kozak Group / Immunoengineering and Regenerative Medicine

Electrospun Wound Dressings

Dressings for chronic wounds should alleviate symptoms, provide wound protection, encourage healing and exert antimicrobial effects in case of infection. As none of the current dressings fulfills all these requirements, the project goal is to create smart wound dressings with improved functionality. Show details 

Müller Group / Laboratory for Bone Biomechanics

Quantitative Analysis of Osteocyte Lacunae

State of the art microCT has allowed researchers to visualise the cell containing voids in the bone, know as lacunae. However analysis of such images is complicated by artefacts caused by physical limitations in the technology. This project aims to develop algorithms to correct for such artefacts. Show details 

Müller Group / Laboratory for Bone Biomechanics

Image-Registration in Fractured Bone

Image registration is an essential tool in bone research, yet existing software can only deal with easy geometries like healthy bone or single fractures. Therefore, the present study will investigate possibilities to register 3D images with higher geometrical complexity. Show details 

Würtz-Kozak Group / Immunoengineering and Regenerative Medicine

Changes in the expression of mechanosensors with age and degeneration

This project will investigate whether and how the expression of a specific group of mechanosensors – the TRP Channels – changes with age and degeneration in the human intervertebral disc. Methods used in this project will include qPCR, immunohistochemistry and immunoblotting to investigate expressio Show details 

Müller Group / Laboratory for Bone Biomechanics

Mechano-regulation of bone repair and improvement of compromised defect healing

Delayed fracture repair and formation of non-unions is a major issue in orthopedic surgery. In order to better understand the complex mechanism of mechano-molecular regulation of fracture repair and to assess potential treatment approaches, we use standardized preclinical defect models in mice. Show details 

Tissue Mechanobiology

Real time biological and micromechanical characterisation of live spinal disk tissue for spinal disc repair and tissue engineering.

Real time micromechanical and microstructural characterisation of outer layers of intervertebral disc (annulus fibrosus) through 3D light imaging techniques for enhanced understanding of spinal disk biomechanics. Show details 

Tissue Mechanobiology

Novel electrospun scaffolds for spinal disc repair. Mechanics, biocompatibility and application.

Real time biomechanical characterisation of electrospun polymer scaffolds through 3D light imaging techniques for spinal repair. Show details 

Tissue Mechanobiology

Electrospun polymer nanofibers for tissue engineering and regenerative medicine.

Micromechanical and biological characterization of electro spun polycaprolactone nanofibers for tissue engineering scaffolds and regenerative medicine. Show details 

 
 
Page URL: http://www.biomech.ethz.ch/student-projects.html
25.07.2017
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