Prof. Ralph Müller

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Biomimetic osteocyte culture in 3D printed structures

Osteocytes are widely accepted to be the main mechanosensor in bone. Using micro 3D printing, advanced surface coating technology and live cell microscopy, we are establishing a novel 3D cell model to study the mechanotransduction mechanisms at play. Show details 

Mapping bone cells in vivo within their 3D environment

Bone remodeling is a dynamic process that requires coordinated interactions between different bone cell types. In order to further our understanding in bone metabolism, these cellular networks and their micro-environments must be investigated locally in a site specific manner. Show details 

Implementing a mechanical testing methodology for assessing the flexure stiffness of healed mouse femurs

Assessing the mechanical properties of healed mouse femurs with three point bending tests poses a challenge due to certain test artifacts. Implementation of an experimental, imaging and computational approach will allow accurate determination of these properties. Show details 

Quantitative Analysis of Osteocyte Lacunae

State of the art microCT has allowed researchers to visualise the cell containing voids in the bone, know as lacunae. However analysis of such images is complicated by artefacts caused by physical limitations in the technology. This project aims to develop algorithms to correct for such artefacts. Show details 

Image-Registration in Fractured Bone

Image registration is an essential tool in bone research, yet existing software can only deal with easy geometries like healthy bone or single fractures. Therefore, the present study will investigate possibilities to register 3D images with higher geometrical complexity. Show details 

Mechano-regulation of bone repair and improvement of compromised defect healing

Delayed fracture repair and formation of non-unions is a major issue in orthopedic surgery. In order to better understand the complex mechanism of mechano-molecular regulation of fracture repair and to assess potential treatment approaches, we use standardized preclinical defect models in mice. Show details 

 
 
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Tue Jul 25 04:16:05 CEST 2017
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