Prof. Jess Gerrit Snedeker

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Isolation of circulating tumor cells by adhesive properties

Establishment of an isolation method for sarcoma circulating tumor cells based on cell-matrix adhesion properties Show details 

The influence of microfabricated surface topography and dimensionality on cell adhesion and cellular traction in cancer and stem cells.

Cell generated traction forces and the sensing of the mechanical environment of a cell is vital to the fate of cell lines such as stem cells or cancer metastasis. In this project, the critical factors on surface topography and dimensionality should be found and investigated. Show details 

3D model of Cells and Simulation of Cell tractions

Physical forces generated by cells to its surrounding has been shown to be highly important to its function. In this project, 3D model of cells should be developed that can be used in simulations Show details 

Assessment of the impact of intermittent mechanical loading in the early stages of tendinopathy on tendon healing

The aim of this project is to analyze the effects of intermittent loading on primary human tenocytes seeded on aligned and random oriented electrospun fiber scaffolds that mimic healthy and degenerated tendons, respectively. Show details 

Insilico Cell Mechanics: Finite Element Modelling of cell behaviour in mechanical characterisation

In our group we experimentally analyze the resistance of cells to substrate deformations. In the present project we plan to generate a finite element model of the cell response to biaxial stretching and use it to estimate cell stiffness from the experimental outcomes. Show details 

Recording in real-time: development and implementation of real-time 3D tracking algorithms for observation of biological samples.

The spatio-temporal changes of a living organism happen in real time. Observation of these changes is highly challenging even with cutting edge recording techniques. We are aiming to push this limit with our recently developed functional imaging platform. Show details 

Generation and biomechanical characterization of artificial actomyosin cortices in vitro

The complexity of biological materials is a major limiting factor for the discovery of the basic cues that govern the metastatic process. With this in mind, the selected student will participate in the development of an in vitro model of metastasizing cells. Show details 

Evaluation of morphology dependent mechanical properties of stem cells

Aim of the project: Revealing how does the cell morphology determine the mechanical properties of the cell? Show details 

Gene expression-based purification of primary tenocytes using novel nanostructured RNA probes

The aim of this project is to purify a homogenous population of primary tenocytes from the mouse tail tendons by targeting the gene expression of the tenogenic markers (COLIA2, Scleraxis, and Tenomodulin or Decorin). Show details 

Engineering the Diabetic Tendon Microenvironment

This project aims to engineer a synthetic hydrogel-based cell niche that mimics key aspects of the diabetic tendon extracellular matrix. Patient-derived tendon fibroblasts will be used to construct a more physiologically relevant three-dimensional (3D) model. Show details 

The role of tendon matrix composition in regulating tenocytes fate: A tissue engineering approach.

The goal of this project is to create a 3D in vitro model to study tendon cell-ECM interaction using collagen gels and primary rat tenocytes. Show details 

Comparative biochemical and proteomic analysis of healthy and diseased human tendons

The objectives of this project strive to develop the experimental workflow protocol to analyze the matrix composition of healthy and diseased human tendons. This includes samples preparation, immunostaining, separation and identification of proteins using different mass spectroscopy techniques. Show details 

Tendon-on-a-Chip: Developing and characterizing a multi-channels microfluidic device for studying tendon biology

This goal of this project is to refine and characterize a novel approach in designing microfluidic networks that allow to host tendon-like micro-tissue structures for long-term culturing experiments under mechanical stimulation. Show details 

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Sun Apr 23 03:26:00 CEST 2017
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