Prof. Jess Gerrit Snedeker

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Insilico Cell Mechanics: Finite Element Modelling of cell behaviour in mechanical characterisation

In our group we experimentally analyze the resistance of cells to substrate deformations. In the present project we plan to generate a finite element model of the cell response to biaxial stretching and use it to estimate cell stiffness from the experimental outcomes. Show details 

Recording in real-time: development and implementation of real-time 3D tracking algorithms for observation of biological samples.

The spatio-temporal changes of a living organism happen in real time. Observation of these changes is highly challenging even with cutting edge recording techniques. We are aiming to push this limit with our recently developed functional imaging platform. Show details 

Shape it up: controlled cell morphology relation to mechanical properties

In our group we experimentally characterize the mechanical properties of cells. In the present project we plan to develop and optimize microstructure fabrication techniques to drive cell attachment to well defined patterns to achieve controlled cell shape. Show details 

Evaluation of morphology dependent mechanical properties of stem cells

Aim of the project: Revealing how does the cell morphology determine the mechanical properties of the cell? Show details 

Engineering the Diabetic Tendon Microenvironment

This project aims to engineer a synthetic hydrogel-based cell niche that mimics key aspects of the diabetic tendon extracellular matrix. Patient-derived tendon fibroblasts will be used to construct a more physiologically relevant three-dimensional (3D) model. Show details 

The role of tendon matrix composition in regulating tenocytes fate: A tissue engineering approach.

The goal of this project is to create a 3D in vitro model to study tendon cell-ECM interaction using collagen gels and primary rat tenocytes. Show details 

Tendon-on-a-Chip: Developing and characterizing a multi-channels microfluidic device for studying tendon biology

This goal of this project is to refine and characterize a novel approach in designing microfluidic networks that allow to host tendon-like micro-tissue structures for long-term culturing experiments under mechanical stimulation. Show details 

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